12:00 – 14:30

Registration

14:30 – 14:50

Welcome session/house keeping

14:50 – 16:05

Workshop 1 – Protein science enabling drug discovery

Chair: Linda Öster

14:50 – 15:15

A streamlined, FAIR, ML/AI-enabled protein production workflow to progress AstraZeneca pipeline projects

Lovisa Holmberg-Schiavone, AstraZeneca, Gothenburg, Sweden

15:15 – 15:40

Not all proteins are made equal: matching experimental platforms to protein reagent complexity

Maja Firczuk, GSK, Stevenage, UK

15:40 – 16:05

Target 2035: A Roadmap for Covering the Druggable Proteome with Chemical Tools

Stefan Knapp, SGC Frankfurt, Germany

16:05 – 16:35

Tea and Coffee

16:35 – 17:50

Workshop 2 – High-throughput structural platforms for drug discovery

Chair: Christian Wiesmann

16:35 – 17:00

Development of a joint X-ray and cryo-EM platform for SBDD, Michael Saur, Astex, Cambridge, UK

17:00 – 17:25

Cryo EM and X ray Crystallography in Concert: A Complementary Workflow for Structure Based Drug Discovery, Srinivas Honnappa, Novartis

17:25 – 17:50

Accelerating Cryo-EM for Drug Discovery: A Four-Fold Faster Integrated Workflow from the HiCONNECTS Project
Brice Murciano, Novalix

17:50 – 19:00

Registration/Free Time/ Poster Setup

19:00 –21:00

Welcome Drinks: Exhibition/Dinner

09:00 – 09:15

 Welcome session/house keeping

09:15 – 10:30

Session 1 – Structural insights into GPCR modulation

Chair: Tove Sjögren

09:15 – 09:40

Structure-based optimization of modulators facilitating mechanistic insights into GPCR function

Dietmar Weichert, Boehringer Ingelheim

09:40 – 10:05

Expanding the Allosteric Landscape of GLP-1R: Structural Insights to Guide PAM Design

Maxime Killer, Sanofi, France

10:05 – 10:30

Discovery, biophysical, and structural characterisation of positive allosteric modulators for MRGPRX1
Simon Holton, Nuvisan / Orion Pharma

10:30 – 11:20

Coffee and Exhibition Viewing

11:20 – 12:10

Session 2 – Structural biology for biological and RNA targets

Chair: Dave Brown

11:00 – 11:25

Structure-based Optimization of a Bivalent Vaccine Against Respiratory Syncytial Virus and Human Metapneumovirus

Oliver Acton, AstraZeneca, Cambridge UK

11:25 – 12:00

RNA cryo-EM goes viral

 Tamas Yelland, Evotec

12:00 – 12:50

Gold Sponsor talks

12:10 – 12:20

MiTeGen – ”Take Control of the Cold: Modular and High-Throughput Plunge Cooling with MiTeGen”

12:20 – 12:30

NUVISAN ICB GmbH – ”Nuvisan – Your trusted partner in gene-to-high resolution structure and challenging membrane targets.”

12:30 – 12:40

Thermofisher – “Expanding Access to Structure-Based Drug Discovery with Advanced 200 kV Cryo-EM”

12:40 – 12:50

Nuclera – “Stabilize as you synthesize: cell-free, nanodisc-based production of functional, structure-ready GPCRs”

12:50 – 14:10

Lunch and Exhibition Viewing

14:10 – 15:00

Session 3 – Beyond X-rays: emerging structural methods

Chair: Karl Edman

14:10 – 14:35

New opportunities for neutron scattering applications for drug discovery

Zoe Fisher, European Spallation Source ERIC, Lund, Sweden

14:35 – 15:00

Fragment HDX-MS Workflow for Detecting Low-Affinity Protein: Fragment Interactions

Catarina Malta, iBET Oeiras, Portugal

15:00-15:25

Atom Probe Tomography for Protein Structure Determination

Martin Andersson , Chalmers university of Technolog, Gothenburg, Sweden

15:25 – 16:50

Coffee and Exhibition Viewing

16:50 – 17:35

Session 4 – AI-driven structure prediction and molecular design

Chair: Alexey Rak

15:30 – 15:55

Utility of co-folding methods for fragment-based drug discovery – the drama unfolds

Marcel Verdonk, Astex, Cambridge, UK

15:55 – 16:20

Antibody–Antigen Recognition: From Structure to Machine Learning Guided Antibody Design and Discovery

Monica Fernandez-Quintero, Novo Nordisk foundation, Copenhagen, Denmark

16:50 –17:35

Plenary Talk Gabriele Corso, CEO and cofounder of Boltz

End of Day 1

19:00 – 22:00

Conference dinner

09:00 – 09:05

  House Keeping

09:05 – 10:20

Session 5 – Tackling challenging and undruggable targets

Chair: Andreas Kuglstatter

09:05 – 09:30

An integrated tractability & druggability prediction platform
Yoana Dimitrova, Genentech

09:30 – 09:55

Unlocking a Challenging Drug Target: Mechanistic Insights into the MSH3 ATPase
Ellene Mashalidis, Pfizer

09:55 – 10:20

Development of the macrocyclic KRAS inhibitor AUBE00 through isoform-selective derivatization of the RAS inhibitor LUNA18
Takashi Yamano, Chugai, Japan

10:20 – 10:50

Coffee and Exhibition Viewing

10:50 – 12:05

Session 6 – Structural and biophysical methods: from data quality to drug design

Chair: Djordje Musil

10:50 – 11:15

The enduring value of MX crystallography: accuracy as the foundation

Clemens Vonrhein, Global Phasing, Cambridge, UK

11:15 – 11:40

Cereblon's Hidden Pocket: An Allosteric Switch That Tunes Protein Degradation
Chun-wa Chung, GSK, Stevenage, UK

11:40 – 12:30

Gold Sponsor Talks

11:50 – 12:00

Biortus, “An AI-Enabled Structural Biology Platform for Accelerating Drug Discovery”

12:00 – 12:10

Cube Biotech GmbH – “A semi- automated pipeline for rapid structural characterization of membrane proteins in near-native conditions”

12:10– 12:20

ALPX – “Fast Screening for Tackling Challenging TPD Ternary Complexes via Cryo-EM and Next-Gen Automated Crystal Harvesting at ALPX”

12:20 – 12:30

CryoCloud – “CryoCloud v3.0: truly fast cryo-EM data analysis”

12:30 – 14:00

Lunch and Exhibition Viewing

14:00 – 15:00

Session 7 – Structure-guided drug discovery: Case stories

Chair: Helena Käck

14:00 – 14:10

Poster prize

14:10 – 14:35

Discovery of an oral STING polymerization blocker to treat inflammation

Shuai Chen, Roche, China

14:35 – 15:00

Fragment-supported Discovery and Optimisation of First-in-Class Inhibitors of the DHX8 RNA Helicase
Rob van Montfort, CRUK / Merck KGaA

15:00 – 15:15

Closing Remarks

End of Conference